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IgA Nephropathy

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When Nephrotic Syndrome Comes Back, Your Body Will Give out Five Signals

When Nephrotic Syndrome Comes Back, Your Body Will Give out Five SignalsNephrotic syndrome is characterized by a large amount of proteinuria, which can be relieved mostly after treatment (24h urine protein is less than 1g) or cured clinically (24h urine protein is less than 0.5g).

When the 24-hour urinary protein quantification is greater than 50mg/kg in patients with Nephrotic Syndrome who are already in remission, it indicates the disease comes back. For example, a patient who weighs 50kg will have a recurrence when the urine protein reaches 2.5g in 24 hours.

After relapse, patients often need to be retreated with adequate hormones. Relapse not only prolongs treatment time, but also causes multiple blows to the kidney and may even lead to kidney failure after a relapse.

Early clinical manifestations of recurrent nephrotic syndrome include:

1. Increased bubbles in urine

When nephrotic syndrome returns, albumin in urine increases, and the surface of urine will naturally form foam. For the common person, the urine foam dissipates within a few minutes. When the urine foam does not dissipate for more than ten minutes, it may be that kidney disease has returned.

2. Decreased appetite

Recurrent nephrotic syndrome can cause loss of appetite due to intestinal mucosal edema.

3. Hypoproteinemia

The normal value of plasma albumin is 40-55g/L, and when nephrotic syndrome relapses, the protein is lost from urine and the protein in blood is reduced. When it is less than 30g/L, the hypoalbuminemia will be formed. In addition, patients often have poor appetite so that they can not consume enough protein or have malabsorption, which is also the cause of hypoalbuminemia.

4. Edema of the eyelid and lower limbs

When nephrotic syndrome recurs, because of hypoalbuminemia, and water and sodium retention, double eyelid and lower limb edema will appear. In severe case, systemic edema will appear.

5. Hyperlipidemia

When nephrotic syndrome returns, the liver needs to synthesize more lipoproteins due to protein loss, and lipoprotein breakdown disorder occurs. More synthetic lipids and less decomposition can lead to hyperlipidemia, which increases the risk of blood clots.

Early detection of the recurrence of nephrotic syndrome is very important. It can help prevent the disease from getting worse.

Note: the above material is only for informational purposes. If you have any questions, please consult a physician.

Hope the above information is helpful for you. If you have any other questions on kidney disease or want to get more personalized and professional treatment suggestions, please leave a message below.

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